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solution of 6-ohdahcl (3.0 μg/μl dissolved in saline containing 0.02% ascorbic acid  (Millipore)


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    Millipore solution of 6-ohdahcl (3.0 μg/μl dissolved in saline containing 0.02% ascorbic acid
    Solution Of 6 Ohdahcl (3.0 μg/μl Dissolved In Saline Containing 0.02% Ascorbic Acid, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/saline+solution+with+ascorbic+acid/6+ohda/pm30030752-45-9-24
    Average 90 stars, based on 1 article reviews
    solution of 6-ohdahcl (3.0 μg/μl dissolved in saline containing 0.02% ascorbic acid - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Injection:

    Article Title: Synergistic effect of serotonin 1A and serotonin 1B/D receptor agonists in the treatment of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats.
    Article Snippet: The rats were anesthetized with pentobarbital sodium (purchased from the Chinese domestic market) 50 mg/kg (IP), positioned in a stereotaxic frame and injected 6-OHDA HBr (Sigma Aldrich, 18 μg in 6 μl, dissolved in 0.9% NaCl with 0.02% ascorbic acid) into the medial forebrain bundle at the following coordinates relative to bregma and dural surface, in mm: tooth bar position − 3.3, AP = − 1.8, ML = − 2, DV = − 8.6 and at a rate of 0.5 μl/min, after which the injection cannula was left in place for an additional 2–3 min. Two weeks after surgery the animals were injected apomorphine HCl (Sigma Aldrich, 0.5 mg/kg dissolved in 0.9% NaCl, given IP) and contralateral full body turns were recorded manually over 30 min. Only rats with rotational scores ≥180 turns/30 min were selected for the next experimental stage.

    Article Title: Use of a composition comprising 7-hydroxymatairesinol
    Article Snippet: Animals received a unilateral injection of 6-OHDA (20 μg in 3 μL of saline solution with 0.02% ascorbic acid; Sigma) into the right striatum (1.0 mm anterior, 3.0 mm lateral and 5.0 mm ventral, with respect to bregma and dura) at 1 μL/min using a Hamilton 10 μL syringe with a 26-gauge needle.

    Article Title: Midbrain and Lateral Nucleus Accumbens Dopamine Depletion Affects Free-choice High-fat high-sugar Diet Preference in Male Rats.
    Article Snippet: Hamilton syringes with 33 gauge needles were used to deliver 2 mL of 6-OHDA (Sigma-Aldrich, France; 2.5 mg/mL in 0.9% NaCl with 0.01% ascorbic acid) (Faivre et al., 2020) bilaterally, over 4 min.

    Article Title: Inhibition of Wnt/β-catenin signaling attenuates axonal degeneration in models of Parkinson's disease.
    Article Snippet: There are currently no treatments to delay or prevent Parkinson’s disease (PD), and protective treatments require early administration.. Targeting axonal degeneration in early PD could have an important clinical effect; however, the underlying molecular mechanisms controlling axonal degeneration in PD are not fully understood.. Here, we studied the role of Wnt/β-catenin signaling in axonal degeneration induced by 6-hydroxydopamine (6OHDA) or overexpression of alpha-synuclein (α-Syn) in vitro and in vivo.

    Article Title: The anti-dyskinetic effect of the clinic-ready mGluR 2 positive allosteric modulator AZD8529 in the 6-OHDA-lesioned rat.
    Article Snippet: l-3,4-dihydroxyphenylalanine (l-DOPA) remains the main treatment for motor symptoms of Parkinson’s disease (PD).. However, chronic use is associated with the development of complications such as l-DOPA-induced dyskinesia.. We previously demonstrated that LY-487,379, a highly selective metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulator (PAM), reduces the severity of l-DOPA-induced abnormal involuntary movements (AIMs) in the 6-hydroxydopamine (6-OHDA)-lesioned rat model of PD, without interfering with the anti-parkinsonian action of l-DOPA.

    Article Title: Cell Fate Analysis of Embryonic Ventral Mesencephalic Grafts in the 6-OHDA Model of Parkinson's Disease
    Article Snippet: Under isoflurane anaesthesia (induction 3.5%, follow-up 1.5–2%), the animals received a unilateral injection of 6-OHDA (2 μg/μl in 0.9% saline with 0.1% ascorbic acid; Sigma) into the left medial forebrain bundle using a stereotaxic apparatus and a 10 μl Hamilton syringe.

    Article Title: Clonal Human Fetal Ventral Mesencephalic Dopaminergic Neuron Precursors for Cell Therapy Research
    Article Snippet: Rats received a 6-hydroxydopamine (6-OH-DA) injection (9 μg/3 μl dissolved in 0.9% saline containing 0.2 mg/ml ascorbic acid; Sigma) in the right median forebrain bundle at the following stereotaxic coordinates (tooth bar set at −3.3 mm): antero-posterior, −3.7 mm; medio-lateral, −1.6 mm (both from bregma); dorso-ventral, −8.8 mm from dura.

    Saline:

    Article Title: Synergistic effect of serotonin 1A and serotonin 1B/D receptor agonists in the treatment of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats.
    Article Snippet: The rats were anesthetized with pentobarbital sodium (purchased from the Chinese domestic market) 50 mg/kg (IP), positioned in a stereotaxic frame and injected 6-OHDA HBr (Sigma Aldrich, 18 μg in 6 μl, dissolved in 0.9% NaCl with 0.02% ascorbic acid) into the medial forebrain bundle at the following coordinates relative to bregma and dural surface, in mm: tooth bar position − 3.3, AP = − 1.8, ML = − 2, DV = − 8.6 and at a rate of 0.5 μl/min, after which the injection cannula was left in place for an additional 2–3 min. Two weeks after surgery the animals were injected apomorphine HCl (Sigma Aldrich, 0.5 mg/kg dissolved in 0.9% NaCl, given IP) and contralateral full body turns were recorded manually over 30 min. Only rats with rotational scores ≥180 turns/30 min were selected for the next experimental stage.

    Article Title: Use of a composition comprising 7-hydroxymatairesinol
    Article Snippet: Animals received a unilateral injection of 6-OHDA (20 μg in 3 μL of saline solution with 0.02% ascorbic acid; Sigma) into the right striatum (1.0 mm anterior, 3.0 mm lateral and 5.0 mm ventral, with respect to bregma and dura) at 1 μL/min using a Hamilton 10 μL syringe with a 26-gauge needle.

    Article Title: Midbrain and Lateral Nucleus Accumbens Dopamine Depletion Affects Free-choice High-fat high-sugar Diet Preference in Male Rats.
    Article Snippet: Hamilton syringes with 33 gauge needles were used to deliver 2 mL of 6-OHDA (Sigma-Aldrich, France; 2.5 mg/mL in 0.9% NaCl with 0.01% ascorbic acid) (Faivre et al., 2020) bilaterally, over 4 min.

    Article Title: Inhibition of Wnt/β-catenin signaling attenuates axonal degeneration in models of Parkinson's disease.
    Article Snippet: There are currently no treatments to delay or prevent Parkinson’s disease (PD), and protective treatments require early administration.. Targeting axonal degeneration in early PD could have an important clinical effect; however, the underlying molecular mechanisms controlling axonal degeneration in PD are not fully understood.. Here, we studied the role of Wnt/β-catenin signaling in axonal degeneration induced by 6-hydroxydopamine (6OHDA) or overexpression of alpha-synuclein (α-Syn) in vitro and in vivo.

    Article Title: The anti-dyskinetic effect of the clinic-ready mGluR 2 positive allosteric modulator AZD8529 in the 6-OHDA-lesioned rat.
    Article Snippet: l-3,4-dihydroxyphenylalanine (l-DOPA) remains the main treatment for motor symptoms of Parkinson’s disease (PD).. However, chronic use is associated with the development of complications such as l-DOPA-induced dyskinesia.. We previously demonstrated that LY-487,379, a highly selective metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulator (PAM), reduces the severity of l-DOPA-induced abnormal involuntary movements (AIMs) in the 6-hydroxydopamine (6-OHDA)-lesioned rat model of PD, without interfering with the anti-parkinsonian action of l-DOPA.

    Article Title: Cell Fate Analysis of Embryonic Ventral Mesencephalic Grafts in the 6-OHDA Model of Parkinson's Disease
    Article Snippet: Under isoflurane anaesthesia (induction 3.5%, follow-up 1.5–2%), the animals received a unilateral injection of 6-OHDA (2 μg/μl in 0.9% saline with 0.1% ascorbic acid; Sigma) into the left medial forebrain bundle using a stereotaxic apparatus and a 10 μl Hamilton syringe.

    Article Title: Clonal Human Fetal Ventral Mesencephalic Dopaminergic Neuron Precursors for Cell Therapy Research
    Article Snippet: Rats received a 6-hydroxydopamine (6-OH-DA) injection (9 μg/3 μl dissolved in 0.9% saline containing 0.2 mg/ml ascorbic acid; Sigma) in the right median forebrain bundle at the following stereotaxic coordinates (tooth bar set at −3.3 mm): antero-posterior, −3.7 mm; medio-lateral, −1.6 mm (both from bregma); dorso-ventral, −8.8 mm from dura.



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